TransPOT: "Enhancing University of Crete Medical School Scientific Excellence and Translational Research Potential in Human Diseases"

publications

2015

Pavlopoulos GA, Malliarakis D, Papanikolaou N, Theodosiou T, Enright A., Iliopoulos I. Visualizing Genome and Systems biology: technologies, tools, implementation techniques, trends, past, present and future, GigaScience 2015, in press

Gkouskou KK, Ioannou M, Pavlopoulos A, Georgila K, Siganou A, Nikolaidis G, Kanellis DC, Moore M, Papadakis KA, Kardassis D, Iliopoulos I, McDyer FA, Drakos E and Eliopoulos AG. Apolipoprotein A-I inhibits experimental colitis and colitis-propelled carcinogenesis. Oncogene, in press

Kontaraki JE, Marketou ME, Parthenakis FI, Maragkoudakis S, Zacharis EA, Petousis S, Kochiadakis GE and Vardas PE. Hypertrophic and anti-hypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension. J Am Soc Hypertens, 2015, Published Online: July 31, 2015

Alissafi T, Hatzioannou A, Ioannou M, Sparwasser T, Grün JR, Grützkau A, Verginis P. De Novo–Induced Self-Antigen–Specific Foxp3+ Regulatory T Cells Impair the Accumulation of Inflammatory Dendritic Cells in Draining Lymph Nodes, Journal of Immunology, 2015 Jun 15;194(12):5812-24.

Notas G, Bariotakis M, Kalogrias V, Andrianaki M, Azariadis K, Kampouri E, Theodoropoulou K, Lavrentaki K, Kastrinakis S, M Kampa M, Agouridakis P, Pirintsos S, Castanas E. Tamoxifen induces a pluripotency signature in breast cancer cells and human tumors, Mol Oncol. 2015 Jun 5. pii: S1574-7891(15)00123-4.

Vlahava V.M., Eliopoulos A.G., Sourvinos G. CD40 ligand exhibits a direct antiviral effect on Herpes Simplex Virus type-1 infection via a PI3K-dependent, autophagy-independent mechanism. Cellular Signalling, 27: 1253-1263, 2015.

Kanellis DC, Bursac S, Tsichlis PN, Volarevic S, Eliopoulos AG. Physical and functional interaction of the TPL2 kinase with nucleophosmin. Oncogene. 2015, 34(19):2516-26

Notas G, Bariotakis M, Kalogrias V, Andrianaki M, Azariadis K, Kampouri E, Theodoropoulou K, Lavrentaki K, Kastrinakis S, M Kampa M, Agouridakis P, Pirintsos S, Castanas E. Accurate prediction of severe allergic reactions by a small set of environmental parameters (NDVI, temperature), PLoS One. 2015 Mar 20;10(3):

Oulas A, Pavloudi C, Polymenakou P, Pavlopoulos GA, Papanikolaou N, Kotoulas G, Arvanitidis C, Iliopoulos I. Metagenomics: Tools and Insights for Analyzing Next-Generation Sequencing Data Derived from Biodiversity Studies, Bioinform Biol Insights. 2015 May 5;9:75-88.

Ignea C, Ioannou E, Georgantea P, Loupassaki S, Trikka FA, Kanellis AK, Makris AM, Roussis V, Kampranis SC. Reconstructing the chemical diversity of labdane-type diterpene biosynthesis in yeast. Metab Eng. 2015 Mar; 28:91-103

Papanikolaou N, Pavlopoulos GA, Theodosiou T, Iliopoulos I. Protein-protein interaction predictions using text mining methods. Methods. 2015 Mar;74:47-53.

Pantazi P, Acha-Sagredo A,Papaioannou A, Nikolaidis G,Liloglou T. DNA methylation: its role in transcriptional regulation and association with lung cancer. Research and Reports in Biochemistry. Volume 5, 2015 January, pp 11—30

2014

Papanikolaou N, Pavlopoulos GA, Pafilis E, Theodosiou T, Schneider R, Satagopam VP, Ouzounis CA, Eliopoulos AG, Promponas VJ, Iliopoulos I. BioTextQuest(+): a knowledge integration platform for literature mining and concept discovery. Bioinformatics. 2014 Nov 15;30(22):3249-56.

Pavlaki K, Pontikoglou CG, Demetriadou A, Batsali AK, Damianaki A, Simantirakis E, Kontakis M, Galanopoulos A, Kotsianidis I, Kastrinaki MC, Papadaki HA. Impaired proliferative potential of bone marrow mesenchymal stromal cells in patients with myelodysplastic syndromes is associated with abnormal WNT signaling pathway. Stem Cells Dev. 2014 Jul 15;23(14)

Kontaraki JE, Marketou ME, Zacharis EA, Parthenakis FI, Vardas PE. MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage. American Society of Hypertension. 2014 June 01; 8(6): 368-375

Kalyva A, Parthenakis FI, Marketou ME, Kontaraki JE, Vardas PE. Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies. Muscle Research and Cell Motility, 2014 Apr 18

Marketou ME, Kalyva A, Parthenakis FI, Pontikoglou C, Maragkoudakis S, Kontaraki JE, Chlouverakis G, Zacharis EA, Patrianakos A, Papadaki HA, Vardas PE. Circulating Endothelial Progenitor Cells in Hypertensive Patients With Increased Arterial Stiffness. Clinical Hypertension. 2014 Apr 01;16(4): 295-300

Liljenfeldt L, Gkirtzimanaki K, Vyrla D, Svensson E, Loskog AS, Eliopoulos AG. Enhanced therapeutic anti-tumor immunity induced by co-administration of 5-fluorouracil and adenovirus expressing CD40 ligand. Cancer Immunol Immunother. 2014 Mar;63(3): 273-82.

Gkouskou KK, Deligianni C, Tsatsanis C, Eliopoulos AG. The gut microbiota in mouse models of inflammatory bowel disease. Front Cell Infect Microbiol. 2014 Feb 28; 4:28.

Vergadi E, Vaporidi K, Theodorakis EE, Doxaki C, Lagoudaki E, Ieronymaki E, Alexaki VI, Helms M, Kondili E, Soennichsen B, Stathopoulos EN, Margioris AN, Georgopoulos D, Tsatsanis C. Akt2 Deficiency Protects from Acute Lung Injury via Alternative Macrophage Activation and miR-146a Induction in Mice. J Immunol. 2014 Jan 1;192(1): 394-406

Pavlopoulos GA, Promponas VJ, Ouzounis CA, Iliopoulos I. Biological information extraction and co-occurrence analysis. Biomedical Literature Mining Methods in Molecular Biology. Volume 1159, 2014 July 01, pp 77-92

2013

Kontaraki JE, Marketou ME, Zacharis EA, Parthenakis FI, Vardas PE. Differential expression of vascular smooth muscle-modulating microRNAs in human peripheral blood mononuclear cells: novel targets in essential hypertension. J Hum Hypertens. 2013 Nov 28

Miliara S, Gkouskou KK, Sharp TV, Eliopoulos AG. SUMOylation Is Required for Optimal TRAF3 Signaling Capacity. PLoS One. 2013 Nov 18;8(11):e80470.

Pavlopoulos GA, Oulas A, Iacucci E, Sifrim A, Moreau Y, Schneider R, Aerts J, Iliopoulos I. Unraveling genomic variation from next generation sequencing data. BioData Mining. 2013 Jul 25; 6(1):13

Gkirtzimanaki K, Gkouskou KK, Oleksiewicz U, Nikolaidis G, Vyrla D, Liontos M, Pelekanou V, Kanellis DC, Evangelou K, Stathopoulos EN, Field JK, Tsichlis PN, Gorgoulis V, Liloglou T, Eliopoulos AG. TPL2 kinase is a suppressor of lung carcinogenesis. Proc Natl Acad Sci USA. 2013 Apr 16;110(16):E1470-9.

Fanouriakis Al., Boumpas D.T., Bertsias G.K. Pathogenesis and treatment of CNS lupus. Current Opinion in Rheumatology. 2013 Sep; 25(5):577-83

Pavlopoulos GA, Kumar P, Sifrim A, Sakai R, Lin ML, Voet T, Moreau Y, Aerts J. Meander: Visually exploring the structural variome using space-filling curves. Nucleic Acids Research. 2013 June 1; 41(11): 118

2012

Notas G, Alexaki VI, Kampa M, Pelekanou V, Charalampopoulos I, Sabour-Alaoui S, Pediaditakis I, Dessirier V, Gravanis A, Stathopoulos EN, Tsapis A, Castanas E. APRIL Binding to BCMA Activates a JNK2-FOXO3-GADD45 Pathway and Induces a G2/M Cell Growth Arrest in Liver Cells. J Immunol. 2012 Νοv 15; 189 (10): 4748-4758

Genomics Lab
	The award of the TransPOT grant has allowed us to acquire a state-of-the-art laser capture microdissection system and a robotic real-time PCR system for mid and high-throughput analyses. Trained personnel funded by TransPOT ensure the professional use of this equipment and aids users to optimize their experiments when using the facilities. more...

GMP Cell Therapy Unit
	The GMP cell processing unit consists of four positive air-pressure modular clean-rooms covering a total surface of 35m2 inside the main building of the Medical School. more...

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